Dutch Connectome Lab

The dutch connectome lab is a group of neuroscience enthusiasts with all kinds of backgrounds (biology, physics, math, medicine, artificial intelligence) working at the Complex Trait Genetics Lab and the center for neurogenomics and cognitive research, part of the Neurocience Campus Amsterdam, VU Amsterdam and Amsterdam UMC.

Our focus: Integrative brain function depends on efficient functional communication within a massive web of billions to trillions of neuronal connections. All this is happening within what we call our 'brain'. Our research focus is to get a better understanding of the wiring architecture of the brain's network and to understand how abnormal connectivity may lead to neurological and psychiatric brain diseases. One of our recent pets is to map the communication hubs of the brain, examining how they 'rich club' together, at what price and, in particular, why... to keep our 1.5 kg of brain mush together?

Watch our research movie


These are the people of the Dutch Connetome Lab.


Recently published papers

  • Connectome-Based Patterns of First-Episode Medication-Naïve Patients With Schizophrenia
    Cui LB, Wei Y, Xi YB, Griffa A, De Lange SC, Kahn RS, Yin H, Van den Heuvel MP | Schizophrenia Bulletin | 30-03-2019
  • Evolutionary expansion of connectivity between multimodal association areas in the human brain compared with chimpanzees
    Ardesch DJ, Scholtens LH, Li L, Preuss TM, Rilling JK, van den Heuvel MP | Proceedings of the National Academy of Sciences | 13-03-2019
  • A spectrum of routing strategies for brain networks
    Avena-Koenigsberger A, Yan X, Kolchinsky A, van den Heuvel MP, Hagmann P, Sporns O | PLoS computational biology | 08-03-2019
  • Discordant attributes of structural and functional brain connectivity in a two-layer multiplex network
    Lim S, Radicchi F, van den Heuvel MP, Sporns O | Scientific reports | 27-02-2019
  • Brain connectivity alterations in early psychosis: from clinical to neuroimaging staging
    Griffa A, Baumann PS, Klauser P, Mullier E, Cleusix M, Jenni R, van den Heuvel MP, Do KQ, Conus P, Hagmann P | Translational psychiatry | 24-01-2019

more... [ 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2006 | 2005 ]

Our favorites

  • Proportional thresholding in resting-state fMRI functional connectivity networks and consequences for patient-control connectome studies: Issues and recommendations
    van den Heuvel MP, de Lange SC, Zalesky A, Seguin C, Yeo T, Schmidt R | Neuroimage. | 01-02-2017
  • Comparative Connectomics
    van den Heuvel MP, Bullmore ET, Sporns O | Trends Cogn Sci. | 26-03-2016
  • Simulating disease propagation across white matter connectome reveals anatomical substrate for neuropathology staging in amyotrophic lateral sclerosis
    Schmidt R, de Reus MA, Scholtens LH, van den Berg LH, van den Heuvel MP | Neuroimage | 11-04-2015
  • The Laplacian spectrum of neural networks
    de Lange SC, de Reus MA, van den Heuvel MP | Front Comput Neurosci. | 13-01-2014
  • High-cost, high-capacity backbone for global brain communication
    van den Heuvel MP, Kahn RS, Goñi J, Sporns O | Proc Natl Acad Sci U S A. | 10-07-2012

more... [ 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2006 | 2005 ]

Please let us know if you are looking for other resources or data.

Internship positions are available for highly motivated students, who are as excited as us to explore the connectome.

Lab members have wide variety of backgrounds and are working on a broad range of topics, so it is likely that there will be a project of interest for you. To give an impression, we list a few previous projects:

  • Linking connectomes from various modalities (EEG, resting state fMRI, DTI)
  • Studying different modalities of the developing brain
  • Exploring the microscopic connectome of the C. elegans
  • Relating genetics and connectomics in disorders
  • Developing new mathematical tools for network analysis
If you are interested, please contact us through the contact form on this website.

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